The dichotomy of inhibiting nuclear factor kappa-B in pneumonia
نویسندگان
چکیده
منابع مشابه
The dichotomy of inhibiting nuclear factor kappa-B in pneumonia
Activation of nuclear factor kappa-B (NF-κB) results in its translocation from the cytoplasm to the nucleus and binding to the promoters of a large number of genes, including those encoding proinflammatory cytokines and other mediators that can contribute to organ system dysfunction in severe infection. While inhibition of NF-κB activation has been proposed as a therapeutic approach in critical...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2013
ISSN: 1364-8535
DOI: 10.1186/cc12722